5ESG

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73E mutant complexed with itraconazole

5ESG の概要

• エントリーDOI: 10.2210/pdb5esg/pdb
• 関連するPDBエントリー: 5ESE 5ESF 5ESH 5ESI 5ESJ 5ESK 5ESL 5ESM 5ESN
• 分子名称: Lanosterol 14-alpha demethylase, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• 機能のキーワード: cyp51, oxidoreductase-oxidoreducatse inhibitor complex, mutation, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63279.39

構造登録者

Sagatova, A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.A.,Monk, B.C. (登録日: 2015-11-16, 公開日: 2016-11-23, 最終更新日: 2023-09-27)

• 主引用文献: Sagatova, A.A.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C.; Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase.; Antimicrob.Agents Chemother., 62:-, 2018; PubMed: 29263059; DOI: 10.1128/AAC.02242-17

実験手法

X-RAY DIFFRACTION (1.981 Å)