5ESK

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with itraconazole

Summary for 5ESK

Entry DOI	10.2210/pdb5esk/pdb
Related	5ESE 5ESF 5ESG 5ESH 5ESI 5ESJ 5ESL 5ESM 5ESN
Descriptor	Lanosterol 14-alpha demethylase, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
Functional Keywords	cyp51, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Total number of polymer chains	1
Total formula weight	63237.36
Authors	Sagatova, A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2015-11-16, release date: 2016-11-23, Last modification date: 2023-09-27)
Primary citation	Sagatova, A.A.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C. Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase. Antimicrob.Agents Chemother., 62:-, 2018 Cited by PubMed: 29263059 DOI: 10.1128/AAC.02242-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation