5EMJ
Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin
Summary for 5EMJ
Entry DOI | 10.2210/pdb5emj/pdb |
Related | 5EMK 5EML 5EMM |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, SINEFUNGIN, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : O14744 Nucleus: Q9BQA1 |
Total number of polymer chains | 2 |
Total formula weight | 112789.31 |
Authors | Boriack-Sjodin, P.A.,Jin, L. (deposition date: 2015-11-06, release date: 2016-02-24, Last modification date: 2018-04-18) |
Primary citation | Duncan, K.W.,Rioux, N.,Boriack-Sjodin, P.A.,Munchhof, M.J.,Reiter, L.A.,Majer, C.R.,Jin, L.,Johnston, L.D.,Chan-Penebre, E.,Kuplast, K.G.,Porter Scott, M.,Pollock, R.M.,Waters, N.J.,Smith, J.J.,Moyer, M.P.,Copeland, R.A.,Chesworth, R. Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7:162-166, 2016 Cited by PubMed: 26985292DOI: 10.1021/acsmedchemlett.5b00380 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.273 Å) |
Structure validation
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