5ELO

Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and cladosporin

Summary for 5ELO

• Entry DOI: 10.2210/pdb5elo/pdb
• Related: 5ELN
• Descriptor: Lysine--tRNA ligase, LYSINE, cladosporin, ... (6 entities in total)
• Functional Keywords: ssgcid, lysine--trna ligase, cryptosporidium parvum, atp binding, aminoacylation, cladosporin, structural genomics, seattle structural genomics center for infectious disease, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Cryptosporidium parvum (strain Iowa II)
• Total number of polymer chains: 4
• Total formula weight: 248232.91

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2015-11-04, release date: 2016-11-16, Last modification date: 2023-09-27)

• Primary citation: Baragana, B.,Forte, B.,Choi, R.,Nakazawa Hewitt, S.,Bueren-Calabuig, J.A.,Pisco, J.P.,Peet, C.,Dranow, D.M.,Robinson, D.A.,Jansen, C.,Norcross, N.R.,Vinayak, S.,Anderson, M.,Brooks, C.F.,Cooper, C.A.,Damerow, S.,Delves, M.,Dowers, K.,Duffy, J.,Edwards, T.E.,Hallyburton, I.,Horst, B.G.,Hulverson, M.A.,Ferguson, L.,Jimenez-Diaz, M.B.,Jumani, R.S.,Lorimer, D.D.,Love, M.S.,Maher, S.,Matthews, H.,McNamara, C.W.,Miller, P.,O'Neill, S.,Ojo, K.K.,Osuna-Cabello, M.,Pinto, E.,Post, J.,Riley, J.,Rottmann, M.,Sanz, L.M.,Scullion, P.,Sharma, A.,Shepherd, S.M.,Shishikura, Y.,Simeons, F.R.C.,Stebbins, E.E.,Stojanovski, L.,Straschil, U.,Tamaki, F.K.,Tamjar, J.,Torrie, L.S.,Vantaux, A.,Witkowski, B.,Wittlin, S.,Yogavel, M.,Zuccotto, F.,Angulo-Barturen, I.,Sinden, R.,Baum, J.,Gamo, F.J.,Maser, P.,Kyle, D.E.,Winzeler, E.A.,Myler, P.J.,Wyatt, P.G.,Floyd, D.,Matthews, D.,Sharma, A.,Striepen, B.,Huston, C.D.,Gray, D.W.,Fairlamb, A.H.,Pisliakov, A.V.,Walpole, C.,Read, K.D.,Van Voorhis, W.C.,Gilbert, I.H.; Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.; Proc. Natl. Acad. Sci. U.S.A., 2019; PubMed: 30894487; DOI: 10.1073/pnas.1814685116

Experimental method

X-RAY DIFFRACTION (1.9 Å)