5ELO
Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and cladosporin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016020 | cellular_component | membrane |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016020 | cellular_component | membrane |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0016020 | cellular_component | membrane |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue LYS A 601 |
| Chain | Residue |
| A | GLU273 |
| A | HOH907 |
| A | HOH938 |
| A | ARG295 |
| A | GLU311 |
| A | TYR313 |
| A | ASN467 |
| A | TYR469 |
| A | GLU471 |
| A | TRP517 |
| A | KRS602 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue KRS A 602 |
| Chain | Residue |
| A | ARG295 |
| A | GLU297 |
| A | THR302 |
| A | HIS303 |
| A | ASN304 |
| A | PHE307 |
| A | ALA309 |
| A | GLU464 |
| A | LEU465 |
| A | ARG523 |
| A | LYS601 |
| A | HOH899 |
| A | HOH940 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | GLU297 |
| A | HIS303 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | ASP415 |
| A | GLU423 |
| A | GLU457 |
| A | PHE459 |
| A | GLU464 |
| A | HOH809 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue LYS B 601 |
| Chain | Residue |
| B | ALA250 |
| B | ALA271 |
| B | GLU273 |
| B | ARG295 |
| B | GLU311 |
| B | TYR313 |
| B | ASN467 |
| B | TYR469 |
| B | GLU471 |
| B | KRS602 |
| B | HOH870 |
| B | HOH918 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue KRS B 602 |
| Chain | Residue |
| B | ARG295 |
| B | GLU297 |
| B | THR302 |
| B | HIS303 |
| B | ASN304 |
| B | PHE307 |
| B | GLU464 |
| B | LEU465 |
| B | ASN467 |
| B | ARG523 |
| B | LYS601 |
| B | HOH987 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | GLU297 |
| B | HIS303 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue LYS C 601 |
| Chain | Residue |
| C | ALA250 |
| C | GLU273 |
| C | ARG295 |
| C | GLU311 |
| C | TYR313 |
| C | ASN467 |
| C | TYR469 |
| C | GLU471 |
| C | KRS602 |
| C | HOH874 |
| C | HOH875 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue KRS C 602 |
| Chain | Residue |
| C | ARG295 |
| C | GLU297 |
| C | THR302 |
| C | HIS303 |
| C | ASN304 |
| C | PHE307 |
| C | GLU464 |
| C | LEU465 |
| C | ARG523 |
| C | LYS601 |
| C | HOH837 |
| C | HOH979 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 603 |
| Chain | Residue |
| C | GLU297 |
| C | HIS303 |
| C | HOH807 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue LYS D 601 |
| Chain | Residue |
| D | ALA250 |
| D | ALA271 |
| D | GLU273 |
| D | ARG295 |
| D | GLU311 |
| D | TYR313 |
| D | ASN467 |
| D | TYR469 |
| D | GLU471 |
| D | TRP517 |
| D | HOH758 |
| D | HOH828 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue KRS D 602 |
| Chain | Residue |
| D | HIS303 |
| D | ASN304 |
| D | PHE307 |
| D | ALA309 |
| D | GLU464 |
| D | LEU465 |
| D | ARG523 |
| D | HOH866 |
| D | HOH885 |
| D | ARG295 |
| D | GLU297 |
| D | THR302 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 D 603 |
| Chain | Residue |
| C | LYS353 |
| C | CYS354 |
| C | HOH890 |
| D | SER110 |
| D | SER111 |
| D | ILE114 |
| D | HOH723 |
| D | HOH740 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 604 |
| Chain | Residue |
| D | GLU297 |
| D | HIS303 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 605 |
| Chain | Residue |
| D | TRP445 |
| D | HIS446 |
| D | HOH809 |
