5EG3

Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)

5EG3 の概要

• エントリーDOI: 10.2210/pdb5eg3/pdb
• 関連するPDBエントリー: 2PSQ 2PVF 2PVY
• 分子名称: Fibroblast growth factor receptor 2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: signaling complex, tyrosine kinase domain, sh2 domain, recruitment, phosphorylation, transferase-hydrolase complex, transferase/hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52019.62

構造登録者

Huang, Z.,Li, X.,Mohammadi, M. (登録日: 2015-10-26, 公開日: 2016-02-03, 最終更新日: 2023-11-15)

• 主引用文献: Huang, Z.,Marsiglia, W.M.,Basu Roy, U.,Rahimi, N.,Ilghari, D.,Wang, H.,Chen, H.,Gai, W.,Blais, S.,Neubert, T.A.,Mansukhani, A.,Traaseth, N.J.,Li, X.,Mohammadi, M.; Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma.; Mol.Cell, 61:98-110, 2016; PubMed: 26687682; DOI: 10.1016/j.molcel.2015.11.010

実験手法

X-RAY DIFFRACTION (2.606 Å)