5EDI
human PDE10A, 6-Chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20A, H3, Rfree=23.5%
Summary for 5EDI
Entry DOI | 10.2210/pdb5edi/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphodiesterase, pde10, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q9Y233 Q9Y233 |
Total number of polymer chains | 4 |
Total formula weight | 150232.11 |
Authors | Joseph, C.,Rudolph, M.G. (deposition date: 2015-10-21, release date: 2016-03-09, Last modification date: 2016-05-25) |
Primary citation | Kuhn, B.,Guba, W.,Hert, J.,Banner, D.,Bissantz, C.,Ceccarelli, S.,Haap, W.,Korner, M.,Kuglstatter, A.,Lerner, C.,Mattei, P.,Neidhart, W.,Pinard, E.,Rudolph, M.G.,Schulz-Gasch, T.,Woltering, T.,Stahl, M. A Real-World Perspective on Molecular Design. J.Med.Chem., 59:4087-4102, 2016 Cited by PubMed: 26878596DOI: 10.1021/acs.jmedchem.5b01875 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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