5EDI
human PDE10A, 6-Chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20A, H3, Rfree=23.5%
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS529 |
| A | HIS563 |
| A | ASP564 |
| A | ASP674 |
| A | HOH953 |
| A | HOH960 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 802 |
| Chain | Residue |
| A | HOH940 |
| A | HOH953 |
| A | HOH973 |
| A | ASP564 |
| A | HOH911 |
| A | HOH928 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 5M9 A 803 |
| Chain | Residue |
| A | LEU675 |
| A | VAL678 |
| A | ILE692 |
| A | TYR693 |
| A | PHE696 |
| A | PRO712 |
| A | MET713 |
| A | LYS718 |
| A | GLU721 |
| A | VAL722 |
| A | GLY725 |
| A | GLN726 |
| A | PHE729 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | HIS529 |
| B | HIS563 |
| B | ASP564 |
| B | ASP674 |
| B | HOH960 |
| B | HOH977 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| B | ASP564 |
| B | HOH902 |
| B | HOH922 |
| B | HOH937 |
| B | HOH960 |
| B | HOH979 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue 5M9 B 803 |
| Chain | Residue |
| B | LEU675 |
| B | VAL678 |
| B | ILE692 |
| B | TYR693 |
| B | PHE696 |
| B | MET713 |
| B | LYS718 |
| B | GLU721 |
| B | GLY725 |
| B | GLN726 |
| B | PHE729 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 801 |
| Chain | Residue |
| C | HIS529 |
| C | HIS563 |
| C | ASP564 |
| C | ASP674 |
| C | HOH925 |
| C | HOH938 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 802 |
| Chain | Residue |
| C | ASP564 |
| C | HOH925 |
| C | HOH933 |
| C | HOH937 |
| C | HOH956 |
| C | HOH975 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue 5M9 C 803 |
| Chain | Residue |
| C | LEU675 |
| C | SER677 |
| C | ILE692 |
| C | TYR693 |
| C | PHE696 |
| C | PRO712 |
| C | MET713 |
| C | LYS718 |
| C | GLU721 |
| C | GLY725 |
| C | GLN726 |
| C | PHE729 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 801 |
| Chain | Residue |
| D | HIS529 |
| D | HIS563 |
| D | ASP564 |
| D | ASP674 |
| D | HOH915 |
| D | HOH927 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 802 |
| Chain | Residue |
| D | ASP564 |
| D | HOH901 |
| D | HOH906 |
| D | HOH920 |
| D | HOH925 |
| D | HOH927 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue 5M9 D 803 |
| Chain | Residue |
| D | LEU675 |
| D | SER677 |
| D | ILE692 |
| D | TYR693 |
| D | PHE696 |
| D | PRO712 |
| D | MET713 |
| D | LYS718 |
| D | GLU721 |
| D | GLY725 |
| D | GLN726 |
| D | PHE729 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS563-TYR574 | |
| B | HIS563-TYR574 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | ASN572 | |
| D | SER616 | |
| D | GLN650 | |
| D | MET669 | |
| B | SER616 | |
| B | GLN650 | |
| B | MET669 | |
| C | ASN572 | |
| C | SER616 | |
| C | GLN650 | |
| C | MET669 | |
| D | ASN572 | |
