5EDI

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c2(c(n1nc(nc1c(c2)C)CCc3nc(nn3C)N4CCCC4)C)Cl, micromolar IC50=0.000279

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, D (A, C, D)	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	polymer	319	37090.7	3	UniProt (Q9Y233)	Homo sapiens (Human)
2	B (B)	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	polymer	320	37161.8	1	UniProt (Q9Y233)	Homo sapiens (Human)
3	E, H, K, N (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	F, I, L, O (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5	G, J, M, P (A, B, C, D)	6-chloranyl-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine	non-polymer		359.9	4	Chemie (5M9)
6	Q, R, S, T (A, B, C, D)	water	water		18.0	377	Chemie (HOH)

Sequence modifications

A, C, D: 452 - 770 (UniProt: Q9Y233)

PDB	External Database	Details
Arg 470	Lys 460	conflict

B: 452 - 770 (UniProt: Q9Y233)

PDB	External Database	Details
Arg 470	Lys 460	conflict
Ala 771	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	148433.8
Non-Polymers*	Number of molecules	12
	Total formula weight	1798.3
All*	Total formula weight	150232.1

*Water molecules are not included.