5EDI
human PDE10A, 6-Chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20A, H3, Rfree=23.5%
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, D | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 319 | 37090.7 | 3 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
2 | B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 320 | 37161.8 | 1 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | A, B, C, D | 6-chloranyl-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine | non-polymer | 359.9 | 4 | Chemie (5M9) | |||
6 | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A, C, D: 452 - 770 (UniProt: Q9Y233)
B: 452 - 770 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Arg 470 | Lys 460 | conflict |
PDB | External Database | Details |
---|---|---|
Arg 470 | Lys 460 | conflict |
Ala 771 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 148433.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1798.3 | |
All* | Total formula weight | 150232.1 |