5EDH

human PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03A, H3, Rfree=22.7%

Summary for 5EDH

Entry DOI	10.2210/pdb5edh/pdb
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, pde10, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q9Y233
Total number of polymer chains	4
Total formula weight	147781.17
Authors	Joseph, C.,Rudolph, M.G. (deposition date: 2015-10-21, release date: 2016-03-09, Last modification date: 2016-05-25)
Primary citation	Kuhn, B.,Guba, W.,Hert, J.,Banner, D.,Bissantz, C.,Ceccarelli, S.,Haap, W.,Korner, M.,Kuglstatter, A.,Lerner, C.,Mattei, P.,Neidhart, W.,Pinard, E.,Rudolph, M.G.,Schulz-Gasch, T.,Woltering, T.,Stahl, M. A Real-World Perspective on Molecular Design. J.Med.Chem., 59:4087-4102, 2016 Cited by PubMed: 26878596 DOI: 10.1021/acs.jmedchem.5b01875 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation