5EDH
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n4c(C)n1c(nc(n1)CCc2nc(nn2C)N3CCCC3)c(c4)CC, micromolar IC50=0.0037753
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 316 | 36515.2 | 4 | UniProt (Q9Y233) | Homo sapiens (Human) | |
| 2 | E, H, K, N (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, L, O (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G, J, M, P (A, B, C, D) | 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | non-polymer | 340.4 | 4 | Chemie (5MF) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 526 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 458 - 770 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ala 456 | - | expression tag |
| Ala 457 | - | expression tag |
| Ala 771 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 146060.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1720.6 | |
| All* | Total formula weight | 147781.2 |
