5EDH
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n4c(C)n1c(nc(n1)CCc2nc(nn2C)N3CCCC3)c(c4)CC, micromolar IC50=0.0037753
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS529 |
| A | HIS563 |
| A | ASP564 |
| A | ASP674 |
| A | HOH962 |
| A | HOH966 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 802 |
| Chain | Residue |
| A | HOH966 |
| A | HOH972 |
| A | HOH999 |
| A | ASP564 |
| A | HOH908 |
| A | HOH919 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 5MF A 803 |
| Chain | Residue |
| A | LEU675 |
| A | VAL678 |
| A | ILE692 |
| A | TYR693 |
| A | PHE696 |
| A | PRO712 |
| A | MET713 |
| A | LYS718 |
| A | GLU721 |
| A | VAL722 |
| A | GLY725 |
| A | GLN726 |
| A | PHE729 |
| A | HOH903 |
| A | HOH983 |
| A | HOH1002 |
| A | HOH1027 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | HIS529 |
| B | HIS563 |
| B | ASP564 |
| B | ASP674 |
| B | HOH915 |
| B | HOH975 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| B | ASP564 |
| B | HOH927 |
| B | HOH951 |
| B | HOH960 |
| B | HOH975 |
| B | HOH1004 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue 5MF B 803 |
| Chain | Residue |
| B | LEU675 |
| B | VAL678 |
| B | ILE692 |
| B | TYR693 |
| B | PHE696 |
| B | MET713 |
| B | LYS718 |
| B | GLY725 |
| B | GLN726 |
| B | PHE729 |
| B | HOH924 |
| B | HOH1002 |
| B | HOH1024 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 801 |
| Chain | Residue |
| C | HIS529 |
| C | HIS563 |
| C | ASP564 |
| C | ASP674 |
| C | HOH941 |
| C | HOH954 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 802 |
| Chain | Residue |
| C | ASP564 |
| C | HOH935 |
| C | HOH943 |
| C | HOH954 |
| C | HOH983 |
| C | HOH1001 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residue 5MF C 803 |
| Chain | Residue |
| C | LEU635 |
| C | LEU675 |
| C | VAL678 |
| C | ILE692 |
| C | TYR693 |
| C | PHE696 |
| C | PRO712 |
| C | MET713 |
| C | LYS718 |
| C | GLU721 |
| C | GLY725 |
| C | GLN726 |
| C | PHE729 |
| C | HOH902 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 801 |
| Chain | Residue |
| D | HIS529 |
| D | HIS563 |
| D | ASP564 |
| D | ASP674 |
| D | HOH914 |
| D | HOH923 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 802 |
| Chain | Residue |
| D | ASP564 |
| D | HOH903 |
| D | HOH905 |
| D | HOH923 |
| D | HOH935 |
| D | HOH941 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue 5MF D 803 |
| Chain | Residue |
| D | VAL722 |
| D | GLY725 |
| D | GLN726 |
| D | PHE729 |
| D | HOH901 |
| D | LEU675 |
| D | ILE692 |
| D | TYR693 |
| D | PHE696 |
| D | MET713 |
| D | LYS718 |
| D | GLU721 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS563-TYR574 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
