5EDH

human PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03A, H3, Rfree=22.7%

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 801

Chain	Residue
A	HIS529
A	HIS563
A	ASP564
A	ASP674
A	HOH962
A	HOH966

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 802

Chain	Residue
A	HOH966
A	HOH972
A	HOH999
A	ASP564
A	HOH908
A	HOH919

---

site_id	AC3
Number of Residues	17
Details	binding site for residue 5MF A 803

Chain	Residue
A	LEU675
A	VAL678
A	ILE692
A	TYR693
A	PHE696
A	PRO712
A	MET713
A	LYS718
A	GLU721
A	VAL722
A	GLY725
A	GLN726
A	PHE729
A	HOH903
A	HOH983
A	HOH1002
A	HOH1027

---

site_id	AC4
Number of Residues	6
Details	binding site for residue ZN B 801

Chain	Residue
B	HIS529
B	HIS563
B	ASP564
B	ASP674
B	HOH915
B	HOH975

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG B 802

Chain	Residue
B	ASP564
B	HOH927
B	HOH951
B	HOH960
B	HOH975
B	HOH1004

---

site_id	AC6
Number of Residues	13
Details	binding site for residue 5MF B 803

Chain	Residue
B	LEU675
B	VAL678
B	ILE692
B	TYR693
B	PHE696
B	MET713
B	LYS718
B	GLY725
B	GLN726
B	PHE729
B	HOH924
B	HOH1002
B	HOH1024

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ZN C 801

Chain	Residue
C	HIS529
C	HIS563
C	ASP564
C	ASP674
C	HOH941
C	HOH954

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG C 802

Chain	Residue
C	ASP564
C	HOH935
C	HOH943
C	HOH954
C	HOH983
C	HOH1001

---

site_id	AC9
Number of Residues	14
Details	binding site for residue 5MF C 803

Chain	Residue
C	LEU635
C	LEU675
C	VAL678
C	ILE692
C	TYR693
C	PHE696
C	PRO712
C	MET713
C	LYS718
C	GLU721
C	GLY725
C	GLN726
C	PHE729
C	HOH902

---

site_id	AD1
Number of Residues	6
Details	binding site for residue ZN D 801

Chain	Residue
D	HIS529
D	HIS563
D	ASP564
D	ASP674
D	HOH914
D	HOH923

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MG D 802

Chain	Residue
D	ASP564
D	HOH903
D	HOH905
D	HOH923
D	HOH935
D	HOH941

---

site_id	AD3
Number of Residues	12
Details	binding site for residue 5MF D 803

Chain	Residue
D	VAL722
D	GLY725
D	GLN726
D	PHE729
D	HOH901
D	LEU675
D	ILE692
D	TYR693
D	PHE696
D	MET713
D	LYS718
D	GLU721

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY

Chain	Residue	Details
A	HIS563-TYR574

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF

Chain	Residue	Details
A	ASN572
C	SER616
C	GLN650
C	MET669
D	ASN572
D	SER616
D	GLN650
D	MET669
A	SER616
A	GLN650
A	MET669
B	ASN572
B	SER616
B	GLN650
B	MET669
C	ASN572

---