5EDG

human PDE10A in complex with 3-(2-Chloro-5-phenyl-3H-imidazol-4-yl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one at 2.30A

Summary for 5EDG

Entry DOI	10.2210/pdb5edg/pdb
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	phosphodiesterase, pde10, hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q9Y233 Q9Y233
Total number of polymer chains	4
Total formula weight	148277.63
Authors	Joseph, C.,Rudolph, M.G. (deposition date: 2015-10-21, release date: 2016-03-09, Last modification date: 2016-05-25)
Primary citation	Kuhn, B.,Guba, W.,Hert, J.,Banner, D.,Bissantz, C.,Ceccarelli, S.,Haap, W.,Korner, M.,Kuglstatter, A.,Lerner, C.,Mattei, P.,Neidhart, W.,Pinard, E.,Rudolph, M.G.,Schulz-Gasch, T.,Woltering, T.,Stahl, M. A Real-World Perspective on Molecular Design. J.Med.Chem., 59:4087-4102, 2016 Cited by PubMed: 26878596 DOI: 10.1021/acs.jmedchem.5b01875 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation