5EDG
human PDE10A in complex with 3-(2-Chloro-5-phenyl-3H-imidazol-4-yl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one at 2.30A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS529 |
| A | HIS563 |
| A | ASP564 |
| A | ASP674 |
| A | HOH947 |
| A | HOH977 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 802 |
| Chain | Residue |
| A | HOH924 |
| A | HOH947 |
| A | HOH981 |
| A | ASP564 |
| A | HOH911 |
| A | HOH917 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 5MG A 803 |
| Chain | Residue |
| A | HIS525 |
| A | PHE639 |
| A | LEU675 |
| A | SER677 |
| A | MET713 |
| A | GLN726 |
| A | PHE729 |
| A | HOH951 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | HIS529 |
| B | HIS563 |
| B | ASP564 |
| B | ASP674 |
| B | HOH932 |
| B | HOH960 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| B | ASP564 |
| B | HOH906 |
| B | HOH915 |
| B | HOH932 |
| B | HOH955 |
| B | HOH964 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue 5MG B 803 |
| Chain | Residue |
| B | HIS525 |
| B | LEU675 |
| B | SER677 |
| B | MET713 |
| B | GLN726 |
| B | PHE729 |
| B | HOH930 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 801 |
| Chain | Residue |
| C | HIS529 |
| C | HIS563 |
| C | ASP564 |
| C | ASP674 |
| C | HOH907 |
| C | HOH945 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 802 |
| Chain | Residue |
| C | ASP564 |
| C | HOH907 |
| C | HOH923 |
| C | HOH939 |
| C | HOH956 |
| C | HOH971 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue 5MG C 803 |
| Chain | Residue |
| C | LEU675 |
| C | SER677 |
| C | VAL678 |
| C | PHE696 |
| C | MET713 |
| C | GLN726 |
| C | PHE729 |
| C | VAL733 |
| C | HOH934 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 801 |
| Chain | Residue |
| D | HIS529 |
| D | HIS563 |
| D | ASP564 |
| D | ASP674 |
| D | HOH930 |
| D | HOH935 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 802 |
| Chain | Residue |
| D | ASP564 |
| D | HOH904 |
| D | HOH908 |
| D | HOH929 |
| D | HOH930 |
| D | HOH931 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue 5MG D 803 |
| Chain | Residue |
| D | HIS525 |
| D | LEU675 |
| D | SER677 |
| D | ILE692 |
| D | MET713 |
| D | GLN726 |
| D | PHE729 |
| D | VAL733 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS563-TYR574 | |
| B | HIS563-TYR574 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF |
| Chain | Residue | Details |
| B | ASN572 | |
| D | SER616 | |
| D | GLN650 | |
| D | MET669 | |
| B | SER616 | |
| B | GLN650 | |
| B | MET669 | |
| C | ASN572 | |
| C | SER616 | |
| C | GLN650 | |
| C | MET669 | |
| D | ASN572 |
