5DMK

Crystal Structure of IAg7 in complex with RLGL-WE14

Summary for 5DMK

• Entry DOI: 10.2210/pdb5dmk/pdb
• Descriptor: H-2 class II histocompatibility antigen, A-D alpha chain, beta chain of Major Histocompatibility Complex Class II, I-Ag7,H2-Ab1 protein, CITRATE ANION, ... (4 entities in total)
• Functional Keywords: chromogranin a, type i diabetes, t cell, fusion protein, immune system
• Biological source: Mus musculus; More
• Cellular location: Membrane ; Single-pass type I membrane protein : P04228
• Total number of polymer chains: 8
• Total formula weight: 178717.80

Authors

Wang, Y.,Jin, N.,Dai, S.,Kappler, J.W. (deposition date: 2015-09-08, release date: 2015-10-28, Last modification date: 2016-04-06)

• Primary citation: Jin, N.,Wang, Y.,Crawford, F.,White, J.,Marrack, P.,Dai, S.,Kappler, J.W.; N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.; Proc.Natl.Acad.Sci.USA, 112:13318-13323, 2015; PubMed: 26453556; DOI: 10.1073/pnas.1517862112

Experimental method

X-RAY DIFFRACTION (2.45 Å)