5DLG

Crystal Structure of Human DNA Polymerase Eta Inserting dGMPNPP Opposite O4-Methylhymidine

Summary for 5DLG

• Entry DOI: 10.2210/pdb5dlg/pdb
• Related: 5DLF
• Descriptor: DNA polymerase eta, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(5DB)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... (7 entities in total)
• Functional Keywords: catalytic domain, dna damage, dna-directed dna polymerase, guanosine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, o4-alkylthymidine, o4-methylthymidine, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 55342.64

Authors

Patra, A.,OFlaherty, D.K.,Egli, M. (deposition date: 2015-09-04, release date: 2016-08-10, Last modification date: 2023-09-27)

• Primary citation: O'Flaherty, D.K.,Patra, A.,Su, Y.,Guengerich, F.P.,Egli, M.,Wilds, C.J.; Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.; Chem Sci, 7:4896-4904, 2016; PubMed: 27574558; DOI: 10.1039/C6SC00666C

Experimental method

X-RAY DIFFRACTION (2.351 Å)