5DLF
Crystal Structure of Human DNA Polymerase Eta Inserting dATP Opposite O4-Methylhymidine
Summary for 5DLF
Entry DOI | 10.2210/pdb5dlf/pdb |
Related | 5DLG |
Descriptor | DNA polymerase eta, DNA (5'-D(*C*AP*TP*(5DB)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total) |
Functional Keywords | catalytic domain, dna damage, dna-directed dna polymerase, adenosine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, o4-alkylthymidine, o4-methylthymidine, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 55319.10 |
Authors | Patra, A.,OFlaherty, D.K.,Egli, M. (deposition date: 2015-09-04, release date: 2016-08-10, Last modification date: 2023-09-27) |
Primary citation | O'Flaherty, D.K.,Patra, A.,Su, Y.,Guengerich, F.P.,Egli, M.,Wilds, C.J. Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta. Chem Sci, 7:4896-4904, 2016 Cited by PubMed: 27574558DOI: 10.1039/C6SC00666C PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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