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5DLG

Crystal Structure of Human DNA Polymerase Eta Inserting dGMPNPP Opposite O4-Methylhymidine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003684molecular_functiondamaged DNA binding
A0006281biological_processDNA repair
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue GOL A 501
ChainResidue
AARG24
APRO244
APHE247
ASER248
AGLY276
AGLU277
AHOH610
AHOH627
AHOH655

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 502
ChainResidue
AASP13
AMET14
AASP115
AMG503
AXG4504

site_idAC3
Number of Residues8
Detailsbinding site for residue MG A 503
ChainResidue
AASP13
ASER113
AASP115
AGLU116
AMG502
AXG4504
AHOH641
PDT8

site_idAC4
Number of Residues24
Detailsbinding site for residue XG4 A 504
ChainResidue
AASP13
AMET14
AASP15
ACYS16
APHE17
APHE18
AGLN38
AILE48
ATYR52
AARG55
AARG61
AASP115
ALYS231
AMG502
AMG503
AHOH638
AHOH641
AHOH645
AHOH648
AHOH680
AHOH683
AHOH693
PDT8
TDA5

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO
ChainResidueDetails
AASP13
AMET14
AASP115
AGLU116

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:27284197
ChainResidueDetails
AARG61

226707

PDB entries from 2024-10-30

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