5DKP

Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556.

Summary for 5DKP

Entry DOI	10.2210/pdb5dkp/pdb
Related PRD ID	PRD_000503
Descriptor	ATP-dependent Clp protease proteolytic subunit, agonist ADEP A54556, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, agonist, degradation, antimicrobial, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Neisseria meningitidis serogroup B (strain MC58) More
Total number of polymer chains	56
Total formula weight	663700.30
Authors	Goodreid, J.D.,Janetzko, J.,Santa Maria Jr., J.P.,Wong, K.,Leung, E.,Eger, B.T.,Bryson, S.,Pai, E.F.,Gray-Owen, S.D.,Walker, S.,Houry, W.A.,Batey, R.A. (deposition date: 2015-09-03, release date: 2016-01-27, Last modification date: 2023-11-15)
Primary citation	Goodreid, J.D.,Janetzko, J.,Santa Maria, J.P.,Wong, K.S.,Leung, E.,Eger, B.T.,Bryson, S.,Pai, E.F.,Gray-Owen, S.D.,Walker, S.,Houry, W.A.,Batey, R.A. Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. J.Med.Chem., 59:624-646, 2016 Cited by PubMed: 26818454 DOI: 10.1021/acs.jmedchem.5b01451 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.381 Å)

Structure validation