5DKP
Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556.
Summary for 5DKP
Entry DOI | 10.2210/pdb5dkp/pdb |
Related PRD ID | PRD_000503 |
Descriptor | ATP-dependent Clp protease proteolytic subunit, agonist ADEP A54556, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase, agonist, degradation, antimicrobial, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Neisseria meningitidis serogroup B (strain MC58) More |
Total number of polymer chains | 56 |
Total formula weight | 663700.30 |
Authors | Goodreid, J.D.,Janetzko, J.,Santa Maria Jr., J.P.,Wong, K.,Leung, E.,Eger, B.T.,Bryson, S.,Pai, E.F.,Gray-Owen, S.D.,Walker, S.,Houry, W.A.,Batey, R.A. (deposition date: 2015-09-03, release date: 2016-01-27, Last modification date: 2023-11-15) |
Primary citation | Goodreid, J.D.,Janetzko, J.,Santa Maria, J.P.,Wong, K.S.,Leung, E.,Eger, B.T.,Bryson, S.,Pai, E.F.,Gray-Owen, S.D.,Walker, S.,Houry, W.A.,Batey, R.A. Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. J.Med.Chem., 59:624-646, 2016 Cited by PubMed: 26818454DOI: 10.1021/acs.jmedchem.5b01451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.381 Å) |
Structure validation
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