5DHH

The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)

5DHH の概要

• エントリーDOI: 10.2210/pdb5dhh/pdb
• 関連するPDBエントリー: 4EA3
• 分子名称: Soluble cytochrome b562,Nociceptin receptor, OLEIC ACID, (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol, ... (4 entities in total)
• 機能のキーワード: nociceptin/orphanin fq peptide receptor, nop, orl-1, n/ofq, opioid receptor, g protein-coupled receptor, gpcr, membrane protein, lipidic cubic phase, bret, receptor-ligand conformational pair, structural genomics, psi-biology, gpcr network, signaling protein, psicnt-127
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P41146
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96563.31

構造登録者

Miller, R.L.,Thompson, A.A.,Trapella, C.,Guerrini, R.,Malfacini, D.,Patel, N.,Han, G.W.,Cherezov, V.,Calo, G.,Katritch, V.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2015-08-31, 公開日: 2015-10-21, 最終更新日: 2023-09-27)

• 主引用文献: Miller, R.L.,Thompson, A.A.,Trapella, C.,Guerrini, R.,Malfacini, D.,Patel, N.,Han, G.W.,Cherezov, V.,Calo, G.,Katritch, V.,Stevens, R.C.; The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor.; Structure, 23:2291-2299, 2015; PubMed: 26526853; DOI: 10.1016/j.str.2015.07.024

実験手法

X-RAY DIFFRACTION (3.004 Å)