5DHH
The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Soluble cytochrome b562,Nociceptin receptor | polymer | 424 | 46696.4 | 2 | UniProt (P0ABE7) UniProt (P41146) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,Kappa-type 3 opioid receptor,KOR-3,Orphanin FQ receptor |
| 2 | C, D, E, F, G... (A, B) | OLEIC ACID | non-polymer | 282.5 | 7 | Chemie (OLA) PubChem (965) PubChem (445639) PubChem (637517) | |||
| 3 | H, K (A, B) | (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol | non-polymer | 418.4 | 2 | Chemie (DGW) PubChem (10047612) PubChem (10202139) PubChem (21061235) PubChem (66895929) PubChem (143676781) | |||
| 4 | L (B) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) PubChem (5283468) PubChem (5364833) PubChem (11451146) PubChem (12178130) PubChem (25021708) PubChem (46840179) PubChem (54294270) PubChem (33022) PubChem (54294271) |
Sequence modifications
A, B: -63 - 42 (UniProt: P0ABE7)
A, B: 43 - 339 (UniProt: P41146)
| PDB | External Database | Details |
|---|---|---|
| Asp -73 | - | expression tag |
| Tyr -72 | - | expression tag |
| Lys -71 | - | expression tag |
| Asp -70 | - | expression tag |
| Asp -69 | - | expression tag |
| Asp -68 | - | expression tag |
| Asp -67 | - | expression tag |
| Gly -66 | - | expression tag |
| Ala -65 | - | expression tag |
| Pro -64 | - | expression tag |
| Trp -57 | Met 29 | engineered mutation |
| Ile 38 | His 124 | engineered mutation |
| Leu 42 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 340 | - | expression tag |
| Arg 341 | - | expression tag |
| Pro 342 | - | expression tag |
| Leu 343 | - | expression tag |
| Glu 344 | - | expression tag |
| Val 345 | - | expression tag |
| Leu 346 | - | expression tag |
| Phe 347 | - | expression tag |
| Gln 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Pro 350 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93392.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3170.6 | |
| All* | Total formula weight | 96563.3 |
