5DHH
The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Soluble cytochrome b562,Nociceptin receptor | polymer | 424 | 46696.4 | 2 | UniProt (P0ABE7) UniProt (P41146) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,Kappa-type 3 opioid receptor,KOR-3,Orphanin FQ receptor |
2 | A, B | OLEIC ACID | non-polymer | 282.5 | 7 | Chemie (OLA) | |||
3 | A, B | (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol | non-polymer | 418.4 | 2 | Chemie (DGW) | |||
4 | B | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) |
Sequence modifications
A, B: -63 - 42 (UniProt: P0ABE7)
A, B: 43 - 339 (UniProt: P41146)
PDB | External Database | Details |
---|---|---|
Asp -73 | - | expression tag |
Tyr -72 | - | expression tag |
Lys -71 | - | expression tag |
Asp -70 | - | expression tag |
Asp -69 | - | expression tag |
Asp -68 | - | expression tag |
Asp -67 | - | expression tag |
Gly -66 | - | expression tag |
Ala -65 | - | expression tag |
Pro -64 | - | expression tag |
Trp -57 | Met 29 | engineered mutation |
Ile 38 | His 124 | engineered mutation |
Leu 42 | Arg 128 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 340 | - | expression tag |
Arg 341 | - | expression tag |
Pro 342 | - | expression tag |
Leu 343 | - | expression tag |
Glu 344 | - | expression tag |
Val 345 | - | expression tag |
Leu 346 | - | expression tag |
Phe 347 | - | expression tag |
Gln 348 | - | expression tag |
Gly 349 | - | expression tag |
Pro 350 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 93392.7 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3170.6 | |
All* | Total formula weight | 96563.3 |