5DHH
The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001626 | molecular_function | nociceptin receptor activity |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0009055 | molecular_function | electron transfer activity |
A | 0016020 | cellular_component | membrane |
A | 0020037 | molecular_function | heme binding |
A | 0022900 | biological_process | electron transport chain |
A | 0042597 | cellular_component | periplasmic space |
A | 0046872 | molecular_function | metal ion binding |
B | 0001626 | molecular_function | nociceptin receptor activity |
B | 0004930 | molecular_function | G protein-coupled receptor activity |
B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016020 | cellular_component | membrane |
B | 0020037 | molecular_function | heme binding |
B | 0022900 | biological_process | electron transport chain |
B | 0042597 | cellular_component | periplasmic space |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue OLA A 1201 |
Chain | Residue |
A | TYR89 |
A | ASP147 |
B | VAL1354 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue OLA A 1202 |
Chain | Residue |
A | ALA121 |
A | LYS124 |
A | OLA1204 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue OLA A 1203 |
Chain | Residue |
A | PHE115 |
A | VAL55 |
A | PRO105 |
A | THR109 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue OLA A 1204 |
Chain | Residue |
A | LYS124 |
A | OLA1202 |
B | ARG1304 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue OLA A 1205 |
Chain | Residue |
A | PHE91 |
A | TRP175 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue DGW A 1206 |
Chain | Residue |
A | GLN107 |
A | ASP110 |
A | ILE127 |
A | ASP130 |
A | TYR131 |
A | ILE219 |
A | VAL279 |
A | GLN280 |
A | VAL283 |
A | TYR309 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue OLA B 1501 |
Chain | Residue |
A | LEU67 |
B | PRO1181 |
B | PHE1182 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue OLA B 1502 |
Chain | Residue |
A | ARG240 |
B | LYS1188 |
site_id | AC9 |
Number of Residues | 10 |
Details | binding site for residue DGW B 1503 |
Chain | Residue |
B | GLN1171 |
B | ASP1194 |
B | TYR1195 |
B | MET1198 |
B | ILE1283 |
B | SER1287 |
B | TRP1340 |
B | GLN1344 |
B | THR1369 |
B | TYR1373 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue OLC B 1504 |
Chain | Residue |
A | LEU288 |
A | VAL290 |
B | TYR1153 |
B | ALA1207 |
B | ASP1211 |
B | VAL1225 |
B | LYS1230 |
Functional Information from PROSITE/UniProt
site_id | PS00237 |
Number of Residues | 17 |
Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSTfTLTAMSVDRYVaI |
Chain | Residue | Details |
A | THR136-ILE152 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: axial binding residue |
Chain | Residue | Details |
A | TRP-57 | |
A | ILE38 | |
B | TRP1007 | |
B | ILE1102 |
site_id | SWS_FT_FI2 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=1 |
Chain | Residue | Details |
A | GLY49-TYR74 | |
B | GLY1113-TYR1138 |
site_id | SWS_FT_FI3 |
Number of Residues | 114 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22596163 |
Chain | Residue | Details |
A | VAL75-ASN87 | |
A | ASP147-SER165 | |
A | LEU237-LEU264 | |
B | VAL1139-ASN1151 | |
B | ASP1211-SER1229 | |
B | LEU1301-LEU1328 |
site_id | SWS_FT_FI4 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=2 |
Chain | Residue | Details |
A | ILE88-THR109 | |
B | ILE1152-THR1173 |
site_id | SWS_FT_FI5 |
Number of Residues | 100 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:22596163 |
Chain | Residue | Details |
A | ASP110-LYS124 | |
A | GLY189-TRP211 | |
A | GLN286-ILE300 | |
B | ASP1174-LYS1188 | |
B | GLY1253-TRP1275 | |
B | GLN1350-ILE1364 |
site_id | SWS_FT_FI6 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=3 |
Chain | Residue | Details |
A | THR125-VAL146 | |
B | THR1189-VAL1210 |
site_id | SWS_FT_FI7 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=4 |
Chain | Residue | Details |
A | LYS166-MET188 | |
B | LYS1230-MET1252 |
site_id | SWS_FT_FI8 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=5 |
Chain | Residue | Details |
A | GLY212-SER236 | |
B | GLY1276-SER1300 |
site_id | SWS_FT_FI9 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=6 |
Chain | Residue | Details |
A | VAL265-ALA285 | |
B | VAL1329-ALA1349 |
site_id | SWS_FT_FI10 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=7 |
Chain | Residue | Details |
A | LEU301-LEU322 | |
B | LEU1365-LEU1386 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | SITE: Important for G protein-mediated signaling |
Chain | Residue | Details |
A | ASP110 | |
A | ASP130 | |
B | ASP1174 | |
B | ASP1194 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
Chain | Residue | Details |
A | CYS334 | |
B | CYS1398 |