5DHH
The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001626 | molecular_function | nociceptin receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0001626 | molecular_function | nociceptin receptor activity |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue OLA A 1201 |
| Chain | Residue |
| A | TYR89 |
| A | ASP147 |
| B | VAL1354 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue OLA A 1202 |
| Chain | Residue |
| A | ALA121 |
| A | LYS124 |
| A | OLA1204 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue OLA A 1203 |
| Chain | Residue |
| A | PHE115 |
| A | VAL55 |
| A | PRO105 |
| A | THR109 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue OLA A 1204 |
| Chain | Residue |
| A | LYS124 |
| A | OLA1202 |
| B | ARG1304 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 1205 |
| Chain | Residue |
| A | PHE91 |
| A | TRP175 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue DGW A 1206 |
| Chain | Residue |
| A | GLN107 |
| A | ASP110 |
| A | ILE127 |
| A | ASP130 |
| A | TYR131 |
| A | ILE219 |
| A | VAL279 |
| A | GLN280 |
| A | VAL283 |
| A | TYR309 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue OLA B 1501 |
| Chain | Residue |
| A | LEU67 |
| B | PRO1181 |
| B | PHE1182 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue OLA B 1502 |
| Chain | Residue |
| A | ARG240 |
| B | LYS1188 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue DGW B 1503 |
| Chain | Residue |
| B | GLN1171 |
| B | ASP1194 |
| B | TYR1195 |
| B | MET1198 |
| B | ILE1283 |
| B | SER1287 |
| B | TRP1340 |
| B | GLN1344 |
| B | THR1369 |
| B | TYR1373 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue OLC B 1504 |
| Chain | Residue |
| A | LEU288 |
| A | VAL290 |
| B | TYR1153 |
| B | ALA1207 |
| B | ASP1211 |
| B | VAL1225 |
| B | LYS1230 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSTfTLTAMSVDRYVaI |
| Chain | Residue | Details |
| A | THR136-ILE152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 69 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"22596163","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 78 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"22596163","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for G protein-mediated signaling"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 13 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
