5DHG

The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with C-35 (PSI Community Target)

Summary for 5DHG

• Entry DOI: 10.2210/pdb5dhg/pdb
• Related: 4EA3
• Descriptor: Soluble cytochrome b562,Nociceptin receptor, 1-benzyl-N-{3-[4-(2,6-dichlorophenyl)piperidin-1-yl]propyl}-D-prolinamide, OLEIC ACID, ... (4 entities in total)
• Functional Keywords: nociceptin/orphanin fq peptide receptor, nop, orl-1, n/ofq, opioid receptor, g protein-coupled receptor, gpcr, membrane protein, lipidic cubic phase, bret, receptor-ligand conformational pair, structural genomics, psi-biology, gpcr network, signaling protein, psicnt-127
• Biological source: Escherichia coli; More
• Cellular location: Cell membrane; Multi-pass membrane protein: P41146
• Total number of polymer chains: 2
• Total formula weight: 96110.52

Authors

Miller, R.L.,Thompson, A.A.,Trapella, C.,Guerrini, R.,Malfacini, D.,Patel, N.,Han, G.W.,Cherezov, V.,Calo, G.,Katritch, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2015-08-30, release date: 2015-10-21, Last modification date: 2023-09-27)

• Primary citation: Miller, R.L.,Thompson, A.A.,Trapella, C.,Guerrini, R.,Malfacini, D.,Patel, N.,Han, G.W.,Cherezov, V.,Calo, G.,Katritch, V.,Stevens, R.C.; The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor.; Structure, 23:2291-2299, 2015; PubMed: 26526853; DOI: 10.1016/j.str.2015.07.024

Experimental method

X-RAY DIFFRACTION (3 Å)