5DHG
The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with C-35 (PSI Community Target)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001626 | molecular_function | nociceptin receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0001626 | molecular_function | nociceptin receptor activity |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue DGV A 1201 |
| Chain | Residue |
| A | GLN107 |
| A | GLN280 |
| A | VAL283 |
| A | TYR309 |
| A | ASP110 |
| A | TRP116 |
| A | ASP130 |
| A | TYR131 |
| A | MET134 |
| A | CYS200 |
| A | ILE219 |
| A | SER223 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 1202 |
| Chain | Residue |
| A | LYS124 |
| A | OLA1204 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue OLA A 1203 |
| Chain | Residue |
| A | TYR89 |
| A | ALA143 |
| A | ASP147 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 1204 |
| Chain | Residue |
| A | ALA121 |
| A | OLA1202 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue DGV B 1501 |
| Chain | Residue |
| B | GLN1171 |
| B | ASP1174 |
| B | TRP1180 |
| B | ASP1194 |
| B | TYR1195 |
| B | MET1198 |
| B | CYS1264 |
| B | ILE1283 |
| B | THR1369 |
| B | TYR1373 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue OLC B 1502 |
| Chain | Residue |
| B | TYR1153 |
| B | ALA1207 |
| B | ASP1211 |
| B | VAL1225 |
| B | LYS1230 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue OLA B 1503 |
| Chain | Residue |
| B | PHE1155 |
| B | GLN1232 |
| B | ASN1235 |
| B | TRP1239 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue OLA B 1504 |
| Chain | Residue |
| B | GLY1128 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSTfTLTAMSVDRYVaI |
| Chain | Residue | Details |
| A | THR136-ILE152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP-57 | |
| A | ILE38 | |
| B | TRP1007 | |
| B | ILE1102 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| A | GLY49-TYR74 | |
| B | GLY1113-TYR1138 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 114 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22596163 |
| Chain | Residue | Details |
| A | VAL75-ASN87 | |
| A | ASP147-SER165 | |
| A | LEU237-LEU264 | |
| B | VAL1139-ASN1151 | |
| B | ASP1211-SER1229 | |
| B | LEU1301-LEU1328 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| A | ILE88-THR109 | |
| B | ILE1152-THR1173 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:22596163 |
| Chain | Residue | Details |
| A | ASP110-LYS124 | |
| A | GLY189-TRP211 | |
| A | GLN286-ILE300 | |
| B | ASP1174-LYS1188 | |
| B | GLY1253-TRP1275 | |
| B | GLN1350-ILE1364 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | THR125-VAL146 | |
| B | THR1189-VAL1210 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | LYS166-MET188 | |
| B | LYS1230-MET1252 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | GLY212-SER236 | |
| B | GLY1276-SER1300 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | VAL265-ALA285 | |
| B | VAL1329-ALA1349 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | LEU301-LEU322 | |
| B | LEU1365-LEU1386 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | SITE: Important for G protein-mediated signaling |
| Chain | Residue | Details |
| A | ASP110 | |
| A | ASP130 | |
| B | ASP1174 | |
| B | ASP1194 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS334 | |
| B | CYS1398 |
