5D6E
Structure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31b
Summary for 5D6E
| Entry DOI | 10.2210/pdb5d6e/pdb |
| Descriptor | Methionine aminopeptidase 2, (4R,7S)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate, COBALT (II) ION, ... (5 entities in total) |
| Functional Keywords | methionine aminopeptidase 2, spiroepoxytriazoles, inhibitor, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 42150.69 |
| Authors | Janowski, R.,Miller, A.K.,Niessing, D. (deposition date: 2015-08-12, release date: 2016-01-13, Last modification date: 2024-01-10) |
| Primary citation | Morgen, M.,Jost, C.,Malz, M.,Janowski, R.,Niessing, D.,Klein, C.D.,Gunkel, N.,Miller, A.K. Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity. Acs Chem.Biol., 11:1001-1011, 2016 Cited by PubMed: 26686773DOI: 10.1021/acschembio.5b00755 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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