5D6E
Structure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31b
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 94A A 501 |
| Chain | Residue |
| A | HIS231 |
| A | HIS382 |
| A | ALA414 |
| A | TYR444 |
| A | GLU459 |
| A | CO502 |
| A | CO503 |
| A | HOH633 |
| A | HOH655 |
| A | HOH852 |
| A | HOH861 |
| A | ASP262 |
| A | ASN327 |
| A | LEU328 |
| A | ASN329 |
| A | HIS331 |
| A | ILE338 |
| A | HIS339 |
| A | GLU364 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CO A 502 |
| Chain | Residue |
| A | ASP251 |
| A | ASP262 |
| A | GLU459 |
| A | 94A501 |
| A | CO503 |
| A | HOH655 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue CO A 503 |
| Chain | Residue |
| A | ASP262 |
| A | HIS331 |
| A | GLU364 |
| A | GLU459 |
| A | 94A501 |
| A | CO502 |
| A | HOH655 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue TBU A 504 |
| Chain | Residue |
| A | THR268 |
| A | PHE269 |
| A | HOH615 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue TBU A 505 |
| Chain | Residue |
| A | PRO189 |
| A | PRO189 |
| A | TYR244 |
| A | TYR244 |
| A | HOH778 |
Functional Information from PROSITE/UniProt
| site_id | PS01202 |
| Number of Residues | 17 |
| Details | MAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD |
| Chain | Residue | Details |
| A | ASP246-ASP262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14534293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16134930","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17350258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17636946","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
