5D1U

Anthrax toxin lethal factor with hydroxamic acid inhibitor

5D1U の概要

• エントリーDOI: 10.2210/pdb5d1u/pdb
• 関連するPDBエントリー: 1YQY 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKV 4PKW
• 分子名称: Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: anthrax toxin, lethal factor, metalloproteinase, metalloprotease, structural dynamics, ligand-induced conformational change, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bacillus anthracis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60876.92

構造登録者

Maize, K.M.,Finzel, B.C. (登録日: 2015-08-04, 公開日: 2015-11-11, 最終更新日: 2023-09-27)

• 主引用文献: Kurbanov, E.K.,Chiu, T.L.,Solberg, J.,Francis, S.,Maize, K.M.,Fernandez, J.,Johnson, R.L.,Hawkinson, J.E.,Walters, M.A.,Finzel, B.C.,Amin, E.A.; Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.; J.Med.Chem., 58:8723-8733, 2015; PubMed: 26492514; DOI: 10.1021/acs.jmedchem.5b01446

実験手法

X-RAY DIFFRACTION (2.8503 Å)