5CYM

HIV-1 reverse transcriptase complexed with 4-iodopyrazole

Summary for 5CYM

• Entry DOI: 10.2210/pdb5cym/pdb
• Related: 4GIQ 5CW1 5CXR 5CYQ
• Descriptor: HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (9 entities in total)
• Functional Keywords: 4-bromopyrazole, phasing, influenza endonuclease, fragment screening, transferase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 118358.83

Authors

Bauman, J.D.,Arnold, E. (deposition date: 2015-07-30, release date: 2015-12-30, Last modification date: 2024-03-06)

• Primary citation: Bauman, J.D.,Harrison, J.J.E.K.,Arnold, E.; Rapid experimental SAD phasing and hot spot identification with halogenated fragments; Iucrj, 3:51-60, 2016; DOI: 10.1107/S2052252515021259

Experimental method

X-RAY DIFFRACTION (2.1 Å)