5CWR

Crystal Structure of human DNA polymerase lambda L431A mutant in complex with a one nucleotide DNA gap and dCTP

Summary for 5CWR

Related5CB1
DescriptorDNA polymerase lambda, DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ... (7 entities in total)
Functional Keywordspolymerase lambda, transferase, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus Q9UGP5
Total number of polymer chains8
Total molecular weight86860.35
Authors
Liu, M.S.,Tsai, M.D. (deposition date: 2015-07-28, release date: 2016-02-24, Last modification date: 2016-03-09)
Primary citation
Liu, M.S.,Tsai, H.Y.,Liu, X.X.,Ho, M.C.,Wu, W.J.,Tsai, M.D.
Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138:2389-2398, 2016
PubMed: 26836966 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.5b13368
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.234500.9%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution