5CWR
Crystal Structure of human DNA polymerase lambda L431A mutant in complex with a one nucleotide DNA gap and dCTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0006281 | biological_process | DNA repair |
| A | 0034061 | molecular_function | DNA polymerase activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0006281 | biological_process | DNA repair |
| B | 0034061 | molecular_function | DNA polymerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue DCP A 601 |
| Chain | Residue |
| A | ARG386 |
| A | THR507 |
| A | GLY508 |
| A | ALA510 |
| A | ASN513 |
| A | CA602 |
| A | CA603 |
| A | HOH733 |
| A | HOH740 |
| A | HOH745 |
| A | HOH790 |
| A | GLY416 |
| A | HOH792 |
| P | DC6 |
| T | DG5 |
| A | SER417 |
| A | ARG420 |
| A | GLY426 |
| A | ASP427 |
| A | ASP429 |
| A | TYR505 |
| A | PHE506 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 602 |
| Chain | Residue |
| A | ASP427 |
| A | ASP429 |
| A | ASP490 |
| A | DCP601 |
| A | HOH733 |
| P | DC6 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 603 |
| Chain | Residue |
| A | ASP427 |
| A | ASP429 |
| A | DCP601 |
| A | HOH716 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue DCP B 601 |
| Chain | Residue |
| B | ARG386 |
| B | GLY416 |
| B | SER417 |
| B | ARG420 |
| B | GLY426 |
| B | ASP427 |
| B | ASP429 |
| B | TYR505 |
| B | PHE506 |
| B | THR507 |
| B | GLY508 |
| B | ALA510 |
| B | ASN513 |
| B | CA602 |
| B | CA603 |
| B | HOH724 |
| B | HOH736 |
| B | HOH777 |
| B | HOH778 |
| E | DC6 |
| F | DG5 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 602 |
| Chain | Residue |
| B | ASP427 |
| B | ASP429 |
| B | ASP490 |
| B | DCP601 |
| E | DC6 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 603 |
| Chain | Residue |
| B | ASP427 |
| B | ASP429 |
| B | DCP601 |
| B | HOH717 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
