5C42
Crystal Structure of HIV-1 Reverse Transcriptase (K101P) Variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
Summary for 5C42
Entry DOI | 10.2210/pdb5c42/pdb |
Related | 1FK9 2ZD1 4MFB 5C24 5C25 |
Descriptor | HIV-1 Reverse Transcriptase, p66 subunit, HIV-1 Reverse Transcriptase, p51 subunit, 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile (3 entities in total) |
Functional Keywords | hiv, reverse transcriptase, polymerase, non-nucleoside inhibitor, resistance, transferase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 2 |
Total formula weight | 114385.04 |
Authors | Frey, K.M.,Gray, W.T.,Anderson, K.S. (deposition date: 2015-06-17, release date: 2015-11-11, Last modification date: 2024-03-06) |
Primary citation | Gray, W.T.,Frey, K.M.,Laskey, S.B.,Mislak, A.C.,Spasov, K.A.,Lee, W.G.,Bollini, M.,Siliciano, R.F.,Jorgensen, W.L.,Anderson, K.S. Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance. Acs Med.Chem.Lett., 6:1075-1079, 2015 Cited by PubMed: 26487915DOI: 10.1021/acsmedchemlett.5b00254 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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