5C1M

Crystal structure of active mu-opioid receptor bound to the agonist BU72

Summary for 5C1M

• Entry DOI: 10.2210/pdb5c1m/pdb
• Related: 4DKL
• Descriptor: Mu-type opioid receptor, Nanobody 39, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (8 entities in total)
• Functional Keywords: ligands, mice, agonists, morphinans, activation, receptors, opioid, mu, nanobody, signaling protein-antagonist complex, signaling protein/antagonist
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 49585.21

Authors

Huang, W.J.,Manglik, A.,Venkatakrishnan, A.J.,Laeremans, T.,Feinberg, E.N.,Sanborn, A.L.,Kato, H.E.,Livingston, K.E.,Thorsen, T.S.,Kling, R.,Granier, S.,Gmeiner, P.,Husbands, S.M.,Traynor, J.R.,Weis, W.I.,Steyaert, J.,Dror, R.O.,Kobilka, B.K. (deposition date: 2015-06-15, release date: 2015-08-05, Last modification date: 2023-09-27)

• Primary citation: Huang, W.,Manglik, A.,Venkatakrishnan, A.J.,Laeremans, T.,Feinberg, E.N.,Sanborn, A.L.,Kato, H.E.,Livingston, K.E.,Thorsen, T.S.,Kling, R.C.,Granier, S.,Gmeiner, P.,Husbands, S.M.,Traynor, J.R.,Weis, W.I.,Steyaert, J.,Dror, R.O.,Kobilka, B.K.; Structural insights into mu-opioid receptor activation.; Nature, 524:315-321, 2015; PubMed: 26245379; DOI: 10.1038/nature14886

Experimental method

X-RAY DIFFRACTION (2.07 Å)