5C1M
Crystal structure of active mu-opioid receptor bound to the agonist BU72
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004979 | molecular_function | beta-endorphin receptor activity |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLCTMSVDRYIaV |
| Chain | Residue | Details |
| A | THR153-VAL169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | THR67-TYR91 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | VAL92-ASN104 | |
| A | ASP164-ASN183 | |
| A | LEU254-ARG277 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | ILE105-LEU129 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 39 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | MET130-CYS140 | |
| A | ALA206-TRP228 | |
| A | LEU305-THR312 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | LYS141-VAL163 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | ALA184-MET205 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | GLU229-GLY253 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | ILE278-ALA304 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| A | PHE313-TYR336 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P33535 |
| Chain | Residue | Details |
| A | TYR166 |
