5C1M
Crystal structure of active mu-opioid receptor bound to the agonist BU72
Summary for 5C1M
Entry DOI | 10.2210/pdb5c1m/pdb |
Related | 4DKL |
Descriptor | Mu-type opioid receptor, Nanobody 39, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (8 entities in total) |
Functional Keywords | ligands, mice, agonists, morphinans, activation, receptors, opioid, mu, nanobody, signaling protein-antagonist complex, signaling protein/antagonist |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 49585.21 |
Authors | Huang, W.J.,Manglik, A.,Venkatakrishnan, A.J.,Laeremans, T.,Feinberg, E.N.,Sanborn, A.L.,Kato, H.E.,Livingston, K.E.,Thorsen, T.S.,Kling, R.,Granier, S.,Gmeiner, P.,Husbands, S.M.,Traynor, J.R.,Weis, W.I.,Steyaert, J.,Dror, R.O.,Kobilka, B.K. (deposition date: 2015-06-15, release date: 2015-08-05, Last modification date: 2023-09-27) |
Primary citation | Huang, W.,Manglik, A.,Venkatakrishnan, A.J.,Laeremans, T.,Feinberg, E.N.,Sanborn, A.L.,Kato, H.E.,Livingston, K.E.,Thorsen, T.S.,Kling, R.C.,Granier, S.,Gmeiner, P.,Husbands, S.M.,Traynor, J.R.,Weis, W.I.,Steyaert, J.,Dror, R.O.,Kobilka, B.K. Structural insights into mu-opioid receptor activation. Nature, 524:315-321, 2015 Cited by PubMed: 26245379DOI: 10.1038/nature14886 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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