MeCP2 MBD domain (A140V) in complex with methylated DNA

Summary for 5BT2

DescriptorMethyl-CpG-binding protein 2, DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3'), ... (4 entities in total)
Functional Keywordsa/t run, mecp2, hydration spine, methylated dna, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight23449.56
Ho, K.L.,Chia, J.Y.,Tan, W.S.,Ng, C.L.,Hu, N.J.,Foo, H.L. (deposition date: 2015-06-02, release date: 2016-08-17, Last modification date: 2019-12-25)
Primary citation
Chia, J.Y.,Tan, W.S.,Ng, C.L.,Hu, N.J.,Foo, H.L.,Ho, K.L.
A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence.
Sci Rep, 6:31210-31210, 2016
PubMed: 27502833 (PDB entries with the same primary citation)
DOI: 10.1038/srep31210
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22370 6.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02