5BT2

MeCP2 MBD domain (A140V) in complex with methylated DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Methyl-CpG-binding protein 2	polymer	97	11155.5	1	UniProt (P51608) Pfam (PF01429)	Homo sapiens (Human)	MeCp2
2	B (B)	DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3')	polymer	20	6138.0	1		Homo sapiens
3	C (C)	DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3')	polymer	20	6156.0	1		Homo sapiens
4	D, E, F (A, B, C)	water	water		18.0	141	Chemie (HOH)

Sequence modifications

A: 77 - 167 (UniProt: P51608)

PDB	External Database	Details
Val 140	Ala 140	engineered mutation
His 168	-	expression tag
His 169	-	expression tag
His 170	-	expression tag
His 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	23449.6
All*	Total formula weight	23449.6

*Water molecules are not included.