5BRH

Crystal structure of Trypanosoma cruzi glucokinase in complex with inhibitor DBT-GlcN

Summary for 5BRH

Entry DOI	10.2210/pdb5brh/pdb
Related	2Q2R 5BRD 5BRE 5BRF
Descriptor	Glucokinase 1, putative, 2-deoxy-2-({[(1,1-dioxido-1-benzothiophen-2-yl)methoxy]carbonyl}amino)-beta-D-glucopyranose (3 entities in total)
Functional Keywords	transferase, hexose kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Trypanosoma cruzi (strain CL Brener)
Total number of polymer chains	2
Total formula weight	85256.07
Authors	D'Antonio, E.L.,Perry, K.,Deinema, M.S.,Kearns, S.P.,Frey, T.A. (deposition date: 2015-05-30, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	D'Antonio, E.L.,Deinema, M.S.,Kearns, S.P.,Frey, T.A.,Tanghe, S.,Perry, K.,Roy, T.A.,Gracz, H.S.,Rodriguez, A.,D'Antonio, J. Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase. Mol.Biochem.Parasitol., 204:64-76, 2016 Cited by PubMed: 26778112 DOI: 10.1016/j.molbiopara.2015.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation