5BQB

Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III

Summary for 5BQB

Entry DOI	10.2210/pdb5bqb/pdb
Related	4MY2 5BPU 5BQ8
Descriptor	Norrin, CITRIC ACID, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	wnt signalling pathway, norrie disease protein, cystine-knot like growth factor, ligand for frizzled 4 receptor, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted : Q00604
Total number of polymer chains	4
Total formula weight	55298.23
Authors	Chang, T.-H.,Hsieh, F.-L.,Harlos, K.,Jones, E.Y. (deposition date: 2015-05-28, release date: 2015-07-01, Last modification date: 2024-01-10)
Primary citation	Chang, T.H.,Hsieh, F.L.,Zebisch, M.,Harlos, K.,Elegheert, J.,Jones, E.Y. Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Elife, 4:e06554-, 2015 Cited by PubMed: 26158506 DOI: 10.7554/eLife.06554 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation