5BO9

Structure of human sialyltransferase ST8SiaIII in complex with CMP-3FNeu5Ac and Sia-6S-LacNAc

5BO9 の概要

• エントリーDOI: 10.2210/pdb5bo9/pdb
• 関連するPDBエントリー: 5BO6 5BO7 5BO8
• 分子名称: Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: sialyltransferase, ternary complex, donor, acceptor, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Golgi apparatus membrane ; Single-pass type II membrane protein : O43173
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81544.01

構造登録者

Volkers, G.,Worrall, L.,Strynadka, N.C.J. (登録日: 2015-05-27, 公開日: 2015-07-15, 最終更新日: 2023-09-27)

• 主引用文献: Volkers, G.,Worrall, L.J.,Kwan, D.H.,Yu, C.C.,Baumann, L.,Lameignere, E.,Wasney, G.A.,Scott, N.E.,Wakarchuk, W.,Foster, L.J.,Withers, S.G.,Strynadka, N.C.; Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.; Nat.Struct.Mol.Biol., 22:627-635, 2015; PubMed: 26192331; DOI: 10.1038/nsmb.3060

実験手法

X-RAY DIFFRACTION (2.3 Å)