5BO9
Structure of human sialyltransferase ST8SiaIII in complex with CMP-3FNeu5Ac and Sia-6S-LacNAc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase | polymer | 323 | 37919.0 | 2 | UniProt (O43173) Pfam (PF00777) In PDB | Homo sapiens (Human) | Alpha-2,8-sialyltransferase 8C,8-sialyltransferase III,ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3,Sialyltransferase 8C,SIAT8-C,Sialyltransferase St8Sia III,ST8SiaIII |
| 2 | C, E, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 4 | F, I | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose | branched | 754.7 | 2 | In PDB GlyTouCan (G99745QX) | |||
| 5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | A, B | CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID | non-polymer | 632.4 | 2 | Chemie (CSF) | |||
| 7 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A, B: 81 - 380 (UniProt: O43173)
| PDB | External Database | Details |
|---|---|---|
| Ala 58 | - | expression tag |
| Pro 59 | - | expression tag |
| Glu 60 | - | expression tag |
| His 61 | - | expression tag |
| His 62 | - | expression tag |
| His 63 | - | expression tag |
| His 64 | - | expression tag |
| His 65 | - | expression tag |
| His 66 | - | expression tag |
| Asp 67 | - | expression tag |
| Tyr 68 | - | expression tag |
| Asp 69 | - | expression tag |
| Ile 70 | - | expression tag |
| Pro 71 | - | expression tag |
| Thr 72 | - | expression tag |
| Thr 73 | - | expression tag |
| Glu 74 | - | expression tag |
| Asn 75 | - | expression tag |
| Leu 76 | - | expression tag |
| Tyr 77 | - | expression tag |
| Phe 78 | - | expression tag |
| Gln 79 | - | expression tag |
| Gly 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75838.0 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3777.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1928.5 | |
| All* | Total formula weight | 81544.0 |
