5BNM
E. coli FabH with Small Molecule Inhibitor 1
Summary for 5BNM
Entry DOI | 10.2210/pdb5bnm/pdb |
Related | 5BNR 5BNS 5BQS |
Descriptor | 3-oxoacyl-[acyl-carrier-protein] synthase 3, SULFATE ION, N-{[3'-(hydroxymethyl)biphenyl-4-yl]methyl}benzenesulfonamide, ... (5 entities in total) |
Functional Keywords | fabh, fatty acid synthesis, bacterial enzyme, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli |
Cellular location | Cytoplasm : P0A6R0 |
Total number of polymer chains | 2 |
Total formula weight | 67737.78 |
Authors | Kazmirski, S.L.,McKinney, D.C. (deposition date: 2015-05-26, release date: 2016-05-18, Last modification date: 2024-03-06) |
Primary citation | McKinney, D.C.,Eyermann, C.J.,Gu, R.F.,Hu, J.,Kazmirski, S.L.,Lahiri, S.D.,McKenzie, A.R.,Shapiro, A.B.,Breault, G. Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2:456-464, 2016 Cited by PubMed: 27626097DOI: 10.1021/acsinfecdis.6b00053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report