5BQS

S. Pneumoniae Fabh with small molecule inhibitor 4

Summary for 5BQS

• Entry DOI: 10.2210/pdb5bqs/pdb
• Related: 5BNM 5BNR 5BNS
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, SODIUM ION, 1-{5-[2-chloro-5-(hydroxymethyl)phenyl]pyridin-2-yl}piperidine-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: fabh, fatty acid synthesis, anti-bacterials, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Streptococcus pneumoniae
• Cellular location: Cytoplasm : C1CIR8
• Total number of polymer chains: 2
• Total formula weight: 70352.14

Authors

Kazmirski, S.L.,McKinney, D.C. (deposition date: 2015-05-29, release date: 2016-05-18, Last modification date: 2024-03-06)

• Primary citation: McKinney, D.C.,Eyermann, C.J.,Gu, R.F.,Hu, J.,Kazmirski, S.L.,Lahiri, S.D.,McKenzie, A.R.,Shapiro, A.B.,Breault, G.; Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.; Acs Infect Dis., 2:456-464, 2016; PubMed: 27626097; DOI: 10.1021/acsinfecdis.6b00053

Experimental method

X-RAY DIFFRACTION (1.9 Å)