5AVI
Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 4
Summary for 5AVI
Entry DOI | 10.2210/pdb5avi/pdb |
Descriptor | Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, tert-butyl 2-[[4-[ethanoyl(methyl)amino]phenoxy]methyl]-5-(trifluoromethyl)benzoate, ... (4 entities in total) |
Functional Keywords | agonist, complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q13133 Q15788 |
Total number of polymer chains | 4 |
Total formula weight | 72191.96 |
Authors | Matsui, Y.,Hanzawa, H.,Tamaki, K. (deposition date: 2015-06-16, release date: 2015-08-26, Last modification date: 2023-11-08) |
Primary citation | Matsui, Y.,Yamaguchi, T.,Yamazaki, T.,Yoshida, M.,Arai, M.,Terasaka, N.,Honzumi, S.,Wakabayashi, K.,Hayashi, S.,Nakai, D.,Hanzawa, H.,Tamaki, K. Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists Bioorg.Med.Chem.Lett., 25:3914-3920, 2015 Cited by PubMed: 26238323DOI: 10.1016/J.BMCL.2015.07.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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