5AJJ
Crystal structure of variola virus virulence factor F1L in complex with human Bid BH3 domain
Summary for 5AJJ
Entry DOI | 10.2210/pdb5ajj/pdb |
Related | 5AJK |
Descriptor | HOMOLOG OF VACCINIA VIRUS CDS F1L PUTATIVE, BH3-INTERACTING DOMAIN DEATH AGONIST, GLYCEROL, ... (5 entities in total) |
Functional Keywords | viral protein, bcl-2, apoptosis, poxvirus, bid |
Biological source | VARIOLA VIRUS (SMALLPOX) More |
Cellular location | Cytoplasm . BH3-interacting domain death agonist p15: Mitochondrion membrane . BH3-interacting domain death agonist p13: Mitochondrion membrane . Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane: P55957 |
Total number of polymer chains | 2 |
Total formula weight | 23505.65 |
Authors | Kvansakul, M.,Colman, P.M. (deposition date: 2015-02-25, release date: 2015-03-25, Last modification date: 2024-01-10) |
Primary citation | Marshall, B.,Puthalakath, H.,Caria, S.,Chugh, S.,Doerflinger, M.,Colman, P.M.,Kvansakul, M. Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim. Cell Death Dis., 6:E1680-, 2015 Cited by PubMed: 25766319DOI: 10.1038/CDDIS.2015.52 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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