5AGJ
Crystal structure of the LeuRS editing domain of Candida albicans in complex with the adduct AN2690-AMP
Summary for 5AGJ
Entry DOI | 10.2210/pdb5agj/pdb |
Related | 5AGH 5AGI |
Descriptor | POTENTIAL CYTOSOLIC LEUCYL TRNA SYNTHETASE, [(6-AMINO-9H-PURIN-9-YL)-[5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE]-4'YL]METHYL DIHYDROGEN PHOSPHATE (3 entities in total) |
Functional Keywords | ligase, aminoacyl-trna synthetase, aminoacylation, protein synthesis, proof-reading mechanisms, antifungal target |
Biological source | CANDIDA ALBICANS |
Total number of polymer chains | 1 |
Total formula weight | 29977.73 |
Authors | Zhao, H.,Palencia, A.,Seiradake, E.,Ghaemi, Z.,Luthey-Schulten, Z.,Cusack, S.,Martinis, S.A. (deposition date: 2015-02-02, release date: 2015-07-01, Last modification date: 2024-01-10) |
Primary citation | Zhao, H.,Palencia, A.,Seiradake, E.,Ghaemi, Z.,Cusack, S.,Luthey-Schulten, Z.,Martinis, S. Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight Into the Leucyl-tRNA Synthetase Editing Mechanism. Acs Chem.Biol., 10:2277-, 2015 Cited by PubMed: 26172575DOI: 10.1021/ACSCHEMBIO.5B00291 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report