5AGJ

Crystal structure of the LeuRS editing domain of Candida albicans in complex with the adduct AN2690-AMP

Summary for 5AGJ

Entry DOI	10.2210/pdb5agj/pdb
Related	5AGH 5AGI
Descriptor	POTENTIAL CYTOSOLIC LEUCYL TRNA SYNTHETASE, [(6-AMINO-9H-PURIN-9-YL)-[5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE]-4'YL]METHYL DIHYDROGEN PHOSPHATE (3 entities in total)
Functional Keywords	ligase, aminoacyl-trna synthetase, aminoacylation, protein synthesis, proof-reading mechanisms, antifungal target
Biological source	CANDIDA ALBICANS
Total number of polymer chains	1
Total formula weight	29977.73
Authors	Zhao, H.,Palencia, A.,Seiradake, E.,Ghaemi, Z.,Luthey-Schulten, Z.,Cusack, S.,Martinis, S.A. (deposition date: 2015-02-02, release date: 2015-07-01, Last modification date: 2024-01-10)
Primary citation	Zhao, H.,Palencia, A.,Seiradake, E.,Ghaemi, Z.,Cusack, S.,Luthey-Schulten, Z.,Martinis, S. Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight Into the Leucyl-tRNA Synthetase Editing Mechanism. Acs Chem.Biol., 10:2277-, 2015 Cited by PubMed: 26172575 DOI: 10.1021/ACSCHEMBIO.5B00291 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation