5ACB

Crystal Structure of the Human Cdk12-Cyclink Complex

Summary for 5ACB

Entry DOI	10.2210/pdb5acb/pdb
Descriptor	CYCLIN-K, CYCLIN-DEPENDENT KINASE 12, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide (3 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Nucleus: Q9NYV4
Total number of polymer chains	4
Total formula weight	141446.32
Authors	Dixon Clarke, S.E.,Elkins, J.M.,Pike, A.C.W.,Mackenzie, A.,Goubin, S.,Strain-Damerell, C.,Mahajan, P.,Tallant, C.,Chalk, R.,Wiggers, H.,Kopec, J.,Fitzpatrick, F.,Burgess-Brown, N.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2015-08-14, release date: 2016-06-15, Last modification date: 2016-10-05)
Primary citation	Zhang, T.,Kwiatkowski, N.,Olson, C.M.,Dixon-Clarke, S.E.,Abraham, B.J.,Greifenberg, A.K.,Ficarro, S.B.,Elkins, J.M.,Liang, Y.,Hannett, N.M.,Manz, T.,Hao, M.,Bartkowiak, B.,Greenleaf, A.L.,Marto, J.A.,Geyer, M.,Bullock, A.N.,Young, R.A.,Gray, N.S. Covalent Targeting of Remote Cysteine Residues to Develop Cdk12 and Cdk13 Inhibitors. Nat.Chem.Biol., 12:876-, 2016 Cited by PubMed: 27571479 DOI: 10.1038/NCHEMBIO.2166 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation