5ACB
Crystal Structure of the Human Cdk12-Cyclink Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 5I1 C 2000 |
| Chain | Residue |
| C | ILE733 |
| C | ASP817 |
| C | ASP819 |
| C | GLN1037 |
| C | CYS1039 |
| C | GLU735 |
| C | VAL741 |
| C | LYS743 |
| C | ALA754 |
| C | LYS756 |
| C | PHE813 |
| C | GLU814 |
| C | MET816 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 5I1 D 2000 |
| Chain | Residue |
| D | ILE733 |
| D | VAL741 |
| D | ALA754 |
| D | LYS756 |
| D | PHE813 |
| D | GLU814 |
| D | MET816 |
| D | ASP819 |
| D | GLU825 |
| D | GLN1037 |
| D | CYS1039 |
| D | GLU1041 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGQVYkAkdkdtgel..........VALK |
| Chain | Residue | Details |
| C | ILE733-LYS756 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FlHrDIKcsNILL |
| Chain | Residue | Details |
| C | PHE855-LEU867 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 29 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24662513","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
