5ACB

Crystal Structure of the Human Cdk12-Cyclink Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CYCLIN-K	polymer	259	30443.1	2	UniProt (G3V5E1) Pfam (PF00134) Pfam (PF21797) UniProt (by SIFTS) (O75909)	HOMO SAPIENS (HUMAN)	CCNK
2	C, D (C, D)	CYCLIN-DEPENDENT KINASE 12	polymer	340	39719.9	2	UniProt (Q9NYV4) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	CDC2-RELATED KINASE, ARGININE/SERINE-RICH, CRKRS, CELL DIVISION CYCLE 2-RELATED PROTEIN KINASE 7, CDC2-RELATED PROTEIN KINASE 7, CELL DIVISION PROTEIN KINASE 12, HCDK12
3	E, F (C, D)	N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide	non-polymer		560.1	2	Chemie (5I1)

Sequence modifications

A, B: 11 - 267 (UniProt: G3V5E1)

PDB	External Database	Details
Ser 9	-	expression tag
Met 10	-	expression tag

C, D: 715 - 1052 (UniProt: Q9NYV4)

PDB	External Database	Details
Ser 713	-	expression tag
Met 714	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	140326.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1120.2
All*	Total formula weight	141446.3

*Water molecules are not included.