5A8X
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Summary for 5A8X
Entry DOI | 10.2210/pdb5a8x/pdb |
Related | 5A8Y 5A8Z |
Descriptor | Neutrophil elastase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | trypsin family fold, protease, hydrolase, hydrolase- inhibitor complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 24728.32 |
Authors | vonNussbaum, F.,Li, V.M.,Meibom, D.,Anlauf, S.,Bechem, M.,Delbeck, M.,Gerisch, M.,Harrenga, A.,Karthaus, D.,Lang, D.,Lustig, K.,Mittendorf, J.,Schaefer, M.,Schaefer, S.,Schamberger, J. (deposition date: 2015-07-17, release date: 2016-08-03, Last modification date: 2020-07-29) |
Primary citation | von Nussbaum, F.,Li, V.M.,Meibom, D.,Anlauf, S.,Bechem, M.,Delbeck, M.,Gerisch, M.,Harrenga, A.,Karthaus, D.,Lang, D.,Lustig, K.,Mittendorf, J.,Schafer, M.,Schafer, S.,Schamberger, J. Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model. ChemMedChem, 11:199-206, 2016 Cited by PubMed: 26333652DOI: 10.1002/cmdc.201500269 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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