5A4C

FGFR1 ligand complex

Summary for 5A4C

Entry DOI	10.2210/pdb5a4c/pdb
Related	5A46
Descriptor	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	transferase, kinase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	2
Total formula weight	72174.65
Authors	Klein, T.,Vajpai, N.,Phillips, J.J.,Davies, G.,Holdgate, G.A.,Phillips, C.,Tucker, J.A.,Norman, R.A.,Scott, A.S.,Higazi, D.R.,Lowe, D.,Thompson, G.S.,Breeze, A.L. (deposition date: 2015-06-05, release date: 2015-08-05, Last modification date: 2024-05-08)
Primary citation	Klein, T.,Vajpai, N.,Phillips, J.J.,Davies, G.,Holdgate, G.A.,Phillips, C.,Tucker, J.A.,Norman, R.A.,Scott, A.D.,Higazi, D.R.,Lowe, D.,Thompson, G.S.,Breeze, A.L. Structural and Dynamic Insights Into the Energetics of Activation Loop Rearrangement in Fgfr1 Kinase. Nat.Commun., 6:7877-, 2015 Cited by PubMed: 26203596 DOI: 10.1038/NCOMMS8877 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation